Remdesivir

Remdesivir (I had to add it to spell check). From the maker of the product:

Remdesivir is an investigational nucleotide analog with broad-spectrum antiviral activity – it is not approved anywhere globally for any use.

I had to look some other bits up too:

  • A Nucleotide is a compound consisting of a nucleoside linked to a phosphate group. Nucleotides form the basic structural unit of nucleic acids such as DNA.
  • A phosphate group is made when a phosphorus atom is surrounded by four oxygen atoms and then attached to (one of many) carbon-containing molecules in our bodies.
  • A phosphate group can activate proteins, referred to as phosphorylated. When phosphorylated, a protein is activated and can do a different job, such as carrying a message to another protein in the cell, or even phosphorylating another protein.

:: whew ::

That’s as far as I got down the rabbit hole before I remembered the words of Dr. Fauci:

“The data shows that Remdesivir has a clear-cut, significant, positive effect in diminishing the time to recovery ..”

and

“What it has proven is that a drug can block this virus.”

It does so by blocking an enzyme that the virus uses, slowing the growth / spread within a patient.

You’ve read the results by now: in a small (but significant) test, people who were administered the drug (intravenously) recovered three days sooner (11-14 days) than those in the placebo group. This is significant because:

  • Getting well is always better .. although this cohort would have likely gotten well on their own.
  • Shorter duration is always better .. less time for the virus to do damage to your lungs or other organs.
  • It gives us all some hope .. and helps revise targets for the researchers.

It is not a cure .. you have to have the virus for it to be effective. It slows the growth of the virus so your body can build the antibodies to kill it.

It is good news. Please don’t read my notes above in any way that says otherwise. It doesn’t get us out of the woods .. We still have to avoid undoing all the good we’ve done, and testing is still a critical factor in getting to a ‘newer normal’.

Stay connected. Stay safe. Stay home.

About Michael Coates
I am a pragmatic evangelist. The products, services and solutions I write about fulfill real-world expectations and use cases. I stay up-to-date on real products I use and review, and share my thoughts here. I apply the same lens when designing an architecture, product or when writing papers. I am always looking for ways that technology can create or enhance a business opportunity .. not just technology for technology's sake. My CV says: Seasoned technology executive, leveraging years of experience with enterprise and integration architectural patterns, executed with healthy doses of business acumen and pragmatism. That's me. My web site says: Technology innovations provide a myriad of opportunities for businesses. That said, having the "latest and greatest" for its own sake isn't always a recipe for success. Business successes gained through exploiting innovation relies on analysis of how the new features will enhance your business followed by effective implementation. Goals vary far and wide: streamlining operations, improving customer experience, extending brand, and many more. In all cases, you must identify and collect the metrics you can apply to measure your success. Analysis must be holistic and balanced: business and operational needs must be considered when capitalizing on a new technology asset or opportunity.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this: